Main Sequence Ventures
Est. dry powder
$153.1M
Raised, not yet invested
AUM
$702.6M
Assets under management
Latest fund
$295.5M
Main Sequence Fund 3
Est. cheque size
$1.8M–
From fund sizes
Deals, last 12 months
19
Last seen investing Sep 2026
About Main Sequence Ventures
Main Sequence Ventures invests in Australian founders making use of the publicly-funded research sector. The firm provides seed through Series B capital to start-ups, spin-off companies, and SMEs with a Deep Tech focus. With over 55investments since 2017, Main Sequence manages their portfolio companies through the CSIRO Innovation Fund 1, 2 and 3, which is part of the Australian's Government's National Innovation and Science Agenda.
- Type
- Venture Capital Firm
- Headquarters
- Sydney, New South Wales, Australia
- Stages
- SeedSeries ASeries BSeries CSeries DSeries EEarly Stage
- Est. cheque size
- $1.8M–$12.2M
- Sectors
- Diversified, Information Technology
- Regions
- Australasia
- Strategies
- Pre-Seed, Seed, Series A
Where they invest
From deals and portfolio companies on record
Most frequent rounds
- Seed38
- Series A37
- Series B20
- Series C5
- Series D3
Across 134 deals
Portfolio sectors
- Software15
- Biotechnology6
- Aerospace5
- Renewable Energy4
- Agribusiness3
Across 64 companies
Portfolio countries
- Australia59
- US5
Across 64 companies
Recent investments
Newest 5 of 134
- Unspecified Round$7.2M
Metacognition Pty Ltd
Sep 2026 · Unspecified Round
- Seed$2.1M
Facet Amtech Pty Ltd
Aug 2026 · Seed
- Unspecified Round$4.8M
Kinoxis Therapeutics Pty Ltd
Aug 2026 · Unspecified Round
- Seed$2.5M
Zabidou Pty Ltd.
Aug 2026 · Seed
- Unspecified Round$10M
Emesent Pty Ltd
Jul 2026 · Unspecified Round
Offices
2 locations
- Sydney, New South Wales, AustraliaHQ
- Sydney, New South Wales, Australia
Questions about Main Sequence Ventures
How much does Main Sequence Ventures invest per deal?
Based on the size of its funds, Main Sequence Ventures writes estimated cheques of $1.8M–$12.2M. Lead cheques usually sit at the top of that range and follow-on cheques lower.
What stages does Main Sequence Ventures invest in?
Main Sequence Ventures has invested at Seed, Series A, Series B, Series C, Series D and Series E. Its most frequent rounds on record are Seed, Series A and Series B.
How much capital does Main Sequence Ventures have left to invest?
Main Sequence Ventures has an estimated $153.1M in dry powder: capital it has raised but not yet invested.