# Prolific Machines

Startup profile on Capital Atlas: https://capitalatlas.ai/startups/prolific-machines

- Industry: Biotechnology
- Headquarters: Emeryville, US
- Website: www.prolific-machines.com
- Total disclosed funding: $105M
- Latest round: Series B (Oct 16, 2026)
- Investors on record: 18

## About

Based in California, US, Prolific Machines, Inc. is a developer of a cell manufacturing platform to enable stem cells to be maintained and differentiated, without any recombinant proteins in the feedstock. In May 2024, Prolific Machines raised USD 55 million in Series B funding led by investor Ki Tua Fund, with participation from other investors Mayfield, Shorewind Capital, Darco Capital, Conti Ventures, Footprint Coalition, In-Q-Tel, Energy Ventures, and SOSV. The round was part of a larger USD 86.5 million series B and debt funding.

Prolific Machines Inc.'s core technology utilises a photomolecular platform. The platform’s light-sensitive proteins (LSPs) directly manipulate various cellular processes. These LSPs, naturally occurring in organisms, are engineered and introduced into target cells. Prolific’s platform enhances the production of complex therapeutic proteins, addressing issues like folding, aggregation, and cytotoxicity while enabling post-translational modifications. The technology facilitates the production of valuable food proteins, including those used in supplements and infant formulas. Additionally, Prolific’s control cell differentiation improves yield and structure in cultured meat production. The platform allows for the design and spatial patterning of reproducible disease models, enhancing research and drug development, creating complex tissue structures, and supporting advancements in regenerative medicine.

The company will use the May 2024 funding for commercialization and accelerate its research and development initiatives.

## Funding rounds

- Series B, Oct 16, 2026, $50M — Atoms & Bits, Nant Capital, Breakthrough Energy Ventures, Ki Tua Fund, Mayfield, SOSV
- Series B, Jun 6, 2024, $55M — Mayfield Fund, In-Q-Tel, SOSV, Breakthrough Energy Ventures, Conti Ventures, Darco Capital, FootPrint Coalition, Shorewind Capital, Ki Tua Fund
- Series A, Nov 19, 2021 — SOSV, Kraft Group, Breyer Capital, Breakthrough Energy Ventures, Baruch Future Ventures, Salt Funds Management, Purple Orange Ventures
- Seed, Mar 22, 2021 — SOSV, IndieBio
- Seed, May 25, 2020 — SOSV

## Investors

- SOSV (https://capitalatlas.ai/funds/sosv) — Seed, Series A, Series B
- IndieBio (https://capitalatlas.ai/funds/indiebio) — Seed
- Kraft Group — Series A
- Breyer Capital (https://capitalatlas.ai/funds/breyer-capital) — Series A
- Breakthrough Energy Ventures (https://capitalatlas.ai/funds/breakthrough-energy-ventures) — Series A, Series B
- Baruch Future Ventures — Series A
- Salt Funds Management — Series A
- Purple Orange Ventures (https://capitalatlas.ai/funds/purple-orange-ventures) — Series A
- Mayfield Fund (https://capitalatlas.ai/funds/mayfield-fund) — Series B
- In-Q-Tel (https://capitalatlas.ai/funds/in-q-tel) — Series B
- Conti Ventures — Series B
- Darco Capital — Series B
- FootPrint Coalition (https://capitalatlas.ai/funds/footprint-coalition) — Series B
- Shorewind Capital (https://capitalatlas.ai/funds/shorewind-capital) — Series B
- Ki Tua Fund (https://capitalatlas.ai/funds/ki-tua-fund) — Series B
- Atoms & Bits — Series B
- Nant Capital — Series B
- Mayfield — Series B