# Dyno Therapeutics

Startup profile on Capital Atlas: https://capitalatlas.ai/startups/dyno-therapeutics

- Industry: Biotechnology
- Headquarters: Cambridge, US
- Website: www.dynotx.com
- Total disclosed funding: $109M
- Latest round: Series A (May 6, 2021)
- Investors on record: 8

## About

Founded in 2018 and based in Massachusetts, US, Dyno Therapeutics, Inc. develops gene therapies using artificial intelligence. The company develops machine-guided engineering of adeno-associated virus (AAV) capsids for gene therapy. Dyno Therapeutics employs molecular and synthetic biologists, protein engineers and gene therapy scientists alongside software engineers, data scientists, and AI and machine learning experts. In May 2021, Dyno Therapeutics, Inc. raised USD 100 million in series A funding led by new investor Andreessen Horowitz.

Dyno's CapsidMap™ platform uses artificial intelligence to systematically and rapidly optimize adeno-associated virus capsids, overcoming the limitations of naturally occurring virus capsids by improving targeting ability, payload size, immune evasion and manufacturability. CapsidMap is used by the company’s biopharmaceutical partners to broaden the functionality and enhance the therapeutic impact of their gene therapies.

CapsidMap works in two stages, it first measures capsid properties in high-throughput using next-generation DNA library synthesis and DNA sequencing. With the data obtained from the first stage, CapsidMap generates improved capsid sequences by applying advanced search algorithms using machine learning. Dyno’s comprehensive map of capsid sequence space and AI-powered tools are used to accelerate the design of AAV gene therapies with optimized properties for treating a broader range of diseases. 

Dyno plans to use the financing to accelerate building its CapsidMap platform to design improved vectors targeting liver, muscle, eye and central nervous system disease as well as growing into new areas of lung, heart and kidney disease.

## Funding rounds

- Series A, May 6, 2021, $100M — CRV, Polaris Partners, Lux Capital, GV, Andreessen Horowitz, Casdin Capital, Obvious, KdT Ventures
- Seed, Dec 1, 2018, $9M — CRV, Polaris Partners

## Investors

- CRV (https://capitalatlas.ai/funds/crv) — Seed, Series A
- Polaris Partners (https://capitalatlas.ai/funds/polaris-partners) — Seed, Series A
- Lux Capital (https://capitalatlas.ai/funds/lux-capital) — Series A
- GV (https://capitalatlas.ai/funds/gv) — Series A
- Andreessen Horowitz (https://capitalatlas.ai/funds/andreessen-horowitz) — Series A
- Casdin Capital (https://capitalatlas.ai/funds/casdin-capital) — Series A
- Obvious (https://capitalatlas.ai/funds/obvious) — Series A
- KdT Ventures (https://capitalatlas.ai/funds/kdt-ventures) — Series A