# CrossBridge Bio

Startup profile on Capital Atlas: https://capitalatlas.ai/startups/crossbridge-bio

- Industry: Biotechnology
- Headquarters: Houston, US
- Website: www.crossbridgebio.com/
- Total disclosed funding: $11M
- Latest round: Seed (Oct 29, 2024)
- Investors on record: 5

## About

Founded in 2023 and based in Texas, US, CrossBridge Bio, Inc. focuses on advancing cancer treatments by developing antibody-drug conjugates (ADCs). Michael Torres (CEO), Zhiqiang An, and Kyoji Tsuchikama are the co-founders of the company. In November 2025, CrossBridge Bio, Inc.?received?USD 15 million of?grant?funding?from new investor Cancer Prevention & Research Institute of Texas.

CrossBridge Bio specializes in the development of antibody-drug conjugates (ADCs) that leverage proprietary linker technology to enhance the stability and effectiveness of cancer therapeutics. The company’s core products include a unique enzymatically cleavable linker known as EGCit (GluGlyCit) and branched linkers conjugated to human IgG1 antibodies through microbial transglutaminase (mTG). This technology enables the production of uniform ADCs with controlled drug-to-antibody ratios (DAR), focusing on providing targeted drug delivery systems for oncology-focused pharmaceutical companies and research institutions, primarily in North America and Europe.

CrossBridge Bio's revenue model revolves around partnerships with pharmaceutical and biotechnology companies, offering ADC technology and development services. Revenue is generated through contract agreements that include payments and royalties based on commercialization.

The company plans to utilize the November 2025 funding to finish GLP toxicology studies, enhance manufacturing scale-up, complete analytical tasks, and get ready for submitting an IND, which is scheduled for 2026.

## Funding rounds

- Seed, Oct 29, 2024, $11M — Alexandria Venture Investments, Texas Medical Center Ventures, Linden Lake Venture Capital, Portal Innovations, CE Venture Capital

## Investors

- Alexandria Venture Investments (https://capitalatlas.ai/funds/alexandria-venture-investments) — Seed
- Texas Medical Center Ventures (https://capitalatlas.ai/funds/texas-medical-center-ventures) — Seed
- Linden Lake Venture Capital (https://capitalatlas.ai/funds/linden-lake-venture-capital) — Seed
- Portal Innovations (https://capitalatlas.ai/funds/portal-innovations) — Seed
- CE Venture Capital (https://capitalatlas.ai/funds/ce-venture-capital) — Seed